你的位置:首页 > > > 离子通道研究用多肽毒素 >OD1,有效的Nav1.7通道激活剂
产品详细页![](http://img66.chem17.com/gxhpic_290085bb46/447ecc9164d7b7fea648a872bfb2cb0d131ca2b9b5d7ba5f5772f76275af2e6c3d16153666817ccd.png)
产品介绍
OD1
OD1, a potent Nav1.7 channel activator
OD1,有效的Nav1.7通道激活剂
OD1 is a scorpion peptide that has been isolated initially from the venom of the scorpion Odonthobuthus doriae. OD1 potently inhibits fast inactivation of mammalian channels Nav1.7 (EC50 4.5 nM), Nav1.4 (EC50 10 ± 2 nM) and Nav1.6 (EC50 47 ± 10 nM). OD1 also blocks fast inactivation of the para/tipE insect channel (EC50 80 nM). OD1 weakly affects mammalian Nav1.3 and Nav1.5 (EC50 > 1 μM) and does not affect Nav1.2 and Nav1.8. OD1 induces spontaneous pain when injected in animal in association with our without Veratridine and can be used to test the analgesic effects of Nav1.7 blockers in-vivo.
OD1技术资料
氨基酸序列:
GVRDAYIADDKNCVYTCASNGYCNTECTKNGAESGYCQWIGRYGNACWCIKLPDEVPIRIPGKCR-NH2
二硫键:C13-C64 ; C17-C37 ; C23-C47 ; C27-C49
长度 (aa): 65
分子式: C308H466N90O95S8
分子量:7206.20 Da
外观:White lyophilized solid
可溶性: Water or saline buffer, 5 mg/mL maximum (recommendation)
Counterion: TFA salts
CAS 号:not available
来源:Synthetic
产品信息
货号 | 名称 | 规格 |
N/A | OD1 | 10ug/100ug/500ug/5×100ug |
北京群晓科苑是Smartox Biotechnology授权代理商,如果您对Smartox产品感兴趣,咨询。